Amsterdam-Duivendrecht, The Netherlands, December 4, 2017 – Kiadis Pharma N.V. (“Kiadis Pharma” or the “Company”) (Euronext Amsterdam and Brussels: KDS), a clinical stage biopharmaceutical company developing innovative cell-therapy products to make bone marrow transplantations safer and more effective for patients, today announces that the first patient has been enrolled in the HATCY Phase 3 clinical trial for ATIR101™.
The multinational trial will evaluate the safety and efficacy of ATIR101™ as an adjunctive treatment to blood stem cell transplantation from a half-matched (haploidentical) family donor compared to post-transplant cyclophosphamide (PTCy or ‘Baltimore’ protocol) in adult patients with blood cancer.
Andrew Sandler, Chief Medical Officer of Kiadis Pharma, commented: “We are pleased that the first patient has been enrolled in the Phase 3 trial for our innovative cell-therapy product ATIR101™. Although the ‘Baltimore’ protocol has made haploidentical transplants feasible, a huge unmet need remains due to high relapse rates and occurrence of graft versus host disease.”
Arthur Lahr, Chief Executive Officer of Kiadis Pharma, commented: “The start of this large multinational Phase 3 clinical trial marks another important step in the development of Kiadis. We aim to submit the results from this Phase 3 trial to the US FDA, while we continue to progress the European filing submitted earlier this year to EMA based on our Phase 2 data.”
About the HATCY Phase 3 trial
This Phase 3 trial (ClinicalTrial.gov identifier: NCT02999854; EudraCT number: 2016-004672-21; Kiadis number: CR-AIR-009; Kiadis name: HATCY) will enroll 195 patients in Europe, US and Canada. The primary objective of this randomized, open label, parallel arm Phase 3 trial is to compare safety and efficacy of a haploidentical (half-matched family donor) T-cell depleted hematopoietic stem-cell transplant (HSCT) and adjunctive treatment with ATIR101™ versus a haploidentical T-cell replete HSCT with post-transplant administration of high dose cyclophosphamide in adult patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) or myelodysplastic syndrome (MDS). The primary composite endpoint is graft-versus-host disease free and relapse-free survival (GRFS), secondary endpoints include overall survival (OS). An additional objective of the study is to compare the effect of the two treatments on quality of life and health economics. The study is event driven and the primary analysis will be performed after 93 GRFS event.
